Research in photobiology is currently limited by a lack of devices capable of delivering precise and tunable irradiation to cells in a high-throughput format.This limits researchers to using expensive commercially available or custom-built light sources which make it difficult to replicate, standardize, optimize, and scale experiments.Here we prese
Digital twin mathematical models suggest individualized hemorrhagic shock resuscitation strategies
Abstract Background Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle.This is limited by the short duration of pre-clinical studies and the sparsity of early data in the clinical setting.Methods We sought to bridge this gap by linking preclinical data
Effect of Invasive Pelvic Floor Management in Vaginismus among Reproductive Aged Females-A Case Study
Vaginismus is defined as condition which leads to involuntary vaginal muscle Microphone spasm leading to painful sexual Intercourse.It is also classified as sexual pain disorder.It is one of the most common conditions prevalent among females who experience pain during vaginal intercourse leading to sexual pain disorder.The main objective of the stu
FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans.
Neuropeptides signal through G-protein coupled receptors (GPCRs) to regulate a broad array of animal behaviors and physiological processes.The Caenorhabditis elegans genome encodes approximately 100 predicted neuropeptide receptor GPCRs, but in vivo roles for only a few have been identified.We describe here a role for the GPCR FRPR-4 in the regulat